自身免疫性肝炎发病机制研究现状

Research Status on the Pathogenesis of Autoimmune Hepatitis

自身免疫性肝炎(Autoimmune hepatitis, AIH)是一种由免疫系统异常为特点的以肝细胞受损为主的肝脏疾病,其病因学和发病机制还不明确。常以高γ球蛋白血症、特异性自身抗体的存在和肝脏组织学的典型异常为特征。该疾病可影响任何年龄的个体,不分性别和种族。近年来AIH的发病原因研究越来越受关注,本文针对AIH的发病机制及分期病理诊断作简要综述。

Autoimmune hepatitis (AIH) is a liver disease characterized by abnormal immune system and mainly liver cell damage, and its etiology and pathogenesis are not clear. It is often characterized by hyper γ globulinaemia, the presence of specific autoantibodies, and typical abnormalities in liver histology. The disease can affect individuals of any age, regardless of gender or race. In recent years, the pathogenesis of AIH has attracted more and more attention, and this article briefly reviews the pathogenesis and staged pathological diagnosis of AIH.