内皮糖萼在脓毒血症中的研究进展

Research Progress of Endothelial Glycocalyx in Sepsis

脓毒血症指局部器官或组织感染后细菌、毒素入血造成的多器官功能障碍,是一种由感染引起的全身炎症反应综合征(systemic inflammatory response syndrome, SIRS),其病死率高达30%~50%。糖萼作为血管内皮的组成,是覆盖于血管内皮细胞管腔侧表面的多绒毛状结构,它是炎症反应时最早被损伤的部位之一。研究内皮糖萼是诊治脓毒血症不可或缺的物质。这篇综述是对脓毒血症中糖萼研究进展的总结。

Sepsis refers to the multiple organ dysfunction caused by the blood inflow of bacteria and toxins af-ter local organ or tissue infection. It is a systemic inflammatory response syndrome (SIRS) caused by infection, and its mortality rate is as high as 30%~50%. Calyx, as a component of vascular endo-thelium, is a multivilli structure covering the lumen surface of vascular endothelial cells. It is one of the earliest damaged parts during inflammation. Study on endothelial glycocalyx is an indispensa-ble substance in the diagnosis and treatment of sepsis. This review summarizes the research pro-gress of glycocalyx in sepsis.