转化治疗在结直肠癌肝转移中的研究进展

Research Progress of Conversion Therapy in Colorectal Cancer Liver Metastasis

结直肠癌(colorectal cancer, CRC)在全球发病率位居前列,结直肠癌肝转移(Colorectal liver metas-tases, CRLM)在结直肠癌病程进展中可占据半数以上,目前唯有手术切除可使CRLM患者的达到根治,但仅有不到20%患者初始可行手术切除,针对这一问题,旨为大多数没有手术机会的CRLM患者通过化疗、靶向治疗、局部治疗等方式创造手术机会,转化治疗被提出并应用于临床,本文就转化治疗在CRLM中的进展、治疗方法及疗效做一综述,以期为相关研究提供参考依据。

Colorectal cancer (CRC) has one of the highest incidence rates in the world, and colorectal liver me-tastases (CRLM) can account for more than half of the progression of colorectal cancer. Currently, surgical resection is the only option that can lead to the radical cure of CRLM, but less than 20% of the patients have a feasible chance for surgical resection. However, less than 20% of patients are in-itially feasible for surgical resection. In order to address this problem and to create surgical oppor-tunities for the majority of patients with CRLM who do not have surgical opportunities through chemotherapy, targeted therapy, local therapy, etc., the translational therapy has been proposed and applied in the clinic, and this article provides a review of the progress, treatment methods and efficacy of translational therapy in CRLM, with the purpose of providing a reference basis for the relevant research.