铁蛋白水平与心血管病的研究进展

Research Progress on Ferritin Levels and Cardiovascular Disease

生理状态下,铁能够通过多种途径进入心肌细胞,在能量代谢中发挥重要作用,然而,在持续应激或过载的情况下,会通过芬顿反应损伤机体细胞。铁稳态失调与多种心血管疾病有关,如缺血再灌注损伤、冠状动脉粥样硬化、心肌疾病及心力衰竭等,早期检测铁蛋白水平,维持铁稳态,预防铁超载,探究铁蛋白与心脏疾病之间的相互关系,为心脏疾病的诊治和预后提供新的方向。

Physiologically, iron can enter cardiomyocytes through a variety of pathways and play an important role in energy metabolism, however, in the case of continuous stress or overload, it can damage body cells through the Fenton reaction. Iron homeostasis disorder is related to a variety of cardio-vascular diseases, such as ischemia-reperfusion injury, coronary atherosclerosis, myocardial dis-eases and heart failure, early detection of ferritin levels, maintenance of iron homeostasis, preven-tion of iron overload, exploration of the interrelationship between ferritin and heart diseases, and provide a new direction for the diagnosis and prognosis of heart diseases.