UBE2S在消化系统肿瘤中的研究进展

Research Progress of UBE2S in Digestive Sys-tem Tumors

泛素结合酶2S (UBE2S)作为泛素结合酶(E2)家族成员之一,是一种细胞周期调控的泛素结合酶,在消化系统肿瘤中特异性表达,且表达水平明显高于癌旁组织,同时UBE2S高表达患者预后较差。研究表明UBE2S在口腔鳞癌、食管癌、胃癌、肝细胞癌、胆囊癌和胰腺癌等消化系统肿瘤中发挥促癌的作用,因此UBE2S可能成为消化系统肿瘤早期诊断及预后预测的标志物。本文就UBE2S的结构和功能及其与消化系统肿瘤的研究进展作一综述,为诊治消化系统肿瘤提供理论依据。

Ubiquitin-conjugating enzyme 2S (UBE2S), as a member of Ubiquitin-conjugating enzyme (E2) fam-ily, is an ubiquitin ligase regulated by cell cycle. It is specifically expressed in digestive system tu-mors, and its expression level is significantly higher than that in adjacent tissues. At the same time, patients with high UBE2S expression have poor prognosis. Studies have shown that UBE2S plays a promoting role in digestive system tumors such as oral squamous cell carcinoma, esophageal carci-noma, gastric cancer, liver cancer, gallbladder cancer and pancreatic cancer, so UBE2S may become a marker for early diagnosis and prognosis prediction of digestive system tumors. In this paper, the structure and function of UBE2S and its research progress in digestive system tumors are reviewed, so as to provide theoretical basis for diagnosis and treatment of digestive system tumors.