IgA肾病生物预后预测标志物研究进展

Advances in Biological Prognostic Predictive Markers for IgA Nephropathy

IgA肾病是世界范围内发病率最高的原发性肾小球疾病,其临床表现和预后的个体差异极大,因此早期发现影响预后的因素尤为重要。随着对IgAN发病机制的进一步研究,一些新的、更简便的的生物标志物被发现,包括甘油三酯与高密度脂蛋白胆固醇比值(TG/HDL-C)、微小RNA、IgM的沉积、白细胞介素-6、中性粒细胞–淋巴细胞比值(NLR)、血小板与白蛋白比值(PAR)、血小板与淋巴细胞比值(PLR)等,为早期识别、干预高危患者提供了更多的可能性,都可作为IgA肾病预后预测标志物。

IgA nephropathy is the primary glomerular disease with the highest incidence worldwide, and its clinical manifestations and prognosis are characterized by great individual variability, making early detection of factors affecting prognosis particularly important. With further studies on the patho-genesis of IgAN, some new and easier biomarkers have been discovered, including triglyceride to high-density lipoprotein cholesterol ratio (TG/HDL-C), microRNA, IgM deposition, interleukin-6, neutrophil-lymphocyte ratio (NLR), platelet to albumin ratio (PAR), and platelet-to-lym- phocyte ra-tio (PLR), etc., which provide more possibilities for early identification and intervention in high-risk patients, can all be used as prognostic predictive markers for IgA nephropathy.