sST2在急性心肌梗死后心室重塑中的研究进展

Research Progress of sST2 in Ventricular Remodeling after Acute Myocardial Infarction

急性心肌梗死(acute myocardial infarction, AMI)后会出现左心室形状改变、体积增大、梗死节段心肌变薄和非梗死节段心肌肥厚等病理变化,被称为心室重塑(ventricular remodeling, VR)。这些过程无法通过心内膜活检进行常规评估,但可通过循环中的生物标记物水平反映出来。近几年来相关研究发现多种可反映AMI后VR的生物标志物,其中可溶性致癌抑制因子2 (soluble suppression of tu-morigenicity-2, sST2)与AMI后不良预后相关。本文综述sST2在急性心肌梗死后心室重塑中的研究进展。

Acute myocardial infarction (AMI) is followed by changes in left ventricular shape, increased vol-ume and pathological changes of myocardial thinning in infarcted areas and hypertrophy in non-infarcted segments, termed ventricular remodeling (VR). These processes cannot be assessed routinely by endomyocardial biopsy but can be reflected by circulating levels of biomarkers. In re-cent years, various biomarkers reflecting VR after AMI have been identified, among which soluble suppression of tumorigenicity-2 (sST2) is associated with poor prognosis after AMI. This article re-views the research progress of sST2 in ventricular remodeling after acute myocardial infarction.