瑞马唑仑在老年患者全麻中应用的研究进展

Research Progress of Remazolam for General Anesthesia in Elderly Patients

当今社会老龄化进程加速,老年人口数量剧增。由于老年患者重要器官、系统的功能衰竭,此类患者的麻醉风险远大于其他年龄层的患者。合理地选择老年患者的麻醉用药是提高医疗安全的必要措施。瑞马唑仑是一种新型短效的苯二氮卓类镇静药,清除度高、稳态分布体积小、消除半衰期短、起效快、组织蓄积小、镇静作用可被拮抗。临床研究证明瑞马唑仑已成功用于全麻诱导和维持时,血流动力学更稳定;呼吸、循环抑制作用更轻;麻醉复苏快且复苏质量高;并发症相对更少。本文结合老年患者的病理及生理改变和瑞马唑仑的药理学特点,论述瑞马唑仑用于老年患者麻醉全身麻醉的现状和未来的发展趋势。

The aging process of today’s society is accelerating, and the number of old people is soaring. Due to the failure of vital organs and systems in elderly patients, the risk of anesthesia in such patients is much greater than that in patients of other ages. Reasonable selection of anesthetic drugs for aged patients is a necessary measure to improve medical safety. Remazolam is a new short-acting benzo-diazepine sedative with high clearance, small steady-state distribution volume, short elimination half-life, quick onset, small tissue accumulation and antagonistic sedation. Clinical studies have proved that Remazolam has been successfully used for induction and maintenance of general anes-thesia, and hemodynamics is more stable. Respiratory and circulatory inhibition effect is lighter;Anesthetic resuscitation is fast and high quality;there are relatively few complications. Based on the pathological and physiological changes of elderly patients and the pharmacological characteris-tics of remazolam, the present situation and future development trend of remazolam for general anesthesia in elderly patients were discussed.