肌肉组织中线粒体功能损伤在脓毒症诱发脏器功能障碍研究进展

Research Progress of Mitochondrial Function Impairment in Muscle Tissue in Organ Dysfunction Induced by Sepsis

脓毒症是重症监护室(ICU)最常见的疾病,其主要特征是多脏器功能障碍,而线粒体损伤引发的器官功能障碍是脓毒症的主要并发症。线粒体通过产生三磷酸腺苷(ATP)为机体的各种代谢的关键步骤提供能量。肌肉组织中的细胞内含有大量线粒体,氧化磷酸化异常可能损害ATP的生成,导致生物能量不足,细胞受损,诱发脓毒症性器官功能障碍。

Sepsis is the most common disease in intensive care unit (ICU), which is characterized by multiple organ dysfunction, and organ dysfunction caused by mitochondrial damage is the main complica-tion of sepsis. Mitochondria produce adenosine triphosphate (ATP) to provide energy for various key metabolic steps in the body. There are a large number of mitochondria in the cells of muscle tissue. Abnormal oxidative phosphorylation may damage ATP generation, lead to bioenergy defi-ciency, cell damage, and induce septic organ dysfunction.