慢性乙型肝炎功能治愈可预测性及持续性分析

Predictability and Durability of Functional Cure for Chronic Hepatitis B

HBsAg清除作为慢性乙肝理想的治疗终点能显著减少肝硬化、肝癌以及肝源性死亡的发生风险。然而,极少的患者能获得功能治愈(HBsAg清除),且不同的治疗方式及疗程也是影响功能治愈的重要因素。自发性及NAs诱导的HBsAg清除在慢性乙肝人群中极为罕见,而基于Peg-IFN的治疗能有效提高HBsAg清除率,故识别HBsAg清除的优势人群能挑选更适合的治疗人群、提高慢性乙肝功能治愈。此外,HBsAg清除后的持久性和临床结局已成为研究人员和临床医生关注的热点。故本文从慢性乙型病毒性肝炎功能治愈的可预测性、持久性以及预后等方面展开论述。

HBsAg clearance, as an ideal treatment endpoint for chronic hepatitis B, can significantly reduce the risk of cirrhosis, liver cancer and liver-derived death. However, a few patients can achieve functional cure (HBsAg clearance), different treatment methods and courses are also important factors affect-ing functional cure. Spontaneous and NAs-induced HBsAg clearance is extremely rare in people with chronic hepatitis B, however, Peg-IFN-based treatment can effectively improve the HBsAg clearance rate. Therefore, identifying the advantaged population of HBsAg clearance can select more suitable patients and improve the functional cure of chronic hepatitis B. In addition, the durability of and clinical outcomes after HBsAg clearance has become a focus of researchers and clinicians. Therefore, this article discusses the predictability, durability and prognosis of functional cure in chronic hepa-titis B virus.