血小板减少与早产儿视网膜病变的研究进展

Research Progress on the Association of Platelet Deficiency with Retinopathy of Prematurity

早产儿视网膜病变(retinopathy of prematurity, ROP)是发生在早产儿和低出生体重儿的视网膜血管增殖疾病,ROP的病理机制主要涉及视网膜血管发育不全和病理性新生血管形成。近年来研究发现血小板减少与严重早产儿视网膜病变的发生密切相关,本文针对血小板减少与早产儿视网膜病变的相关研究进展做一综述,为临床诊断与治疗ROP提供新的思考。

Retinopathy of prematurity (ROP) is an abnormal proliferative disease of the retinal vasculature that occurs in preterm and low-birth-weight infants. The pathogenesis of ROP mainly involves reti-nal vascular hypoplasia and pathologic neovascularization. In recent years, it has been found that platelet deficiency is related to the severe retinopathy of prematurity. This review summarizes the current research on platelet deficiency and retinopathy of prematurity, and provides new insights for clinical diagnosis and treatment of ROP.