肠道菌群在治疗老年抑郁患者认知功能障碍中的理论基础及应用前景

Theoretical Basis and Application Prospect of Intestinal Flora in the Treatment of Cognitive Dysfunction in Elderly Patients with Depression

抑郁症目前是最常见的精神疾病之一,在抑郁症患者的群体中,约三分之二的抑郁症患者存在不同程度的认知功能受损,研究表明抑郁症的认知缺陷可能是阿尔茨海默病的前驱症状,但其发生机制尚不明确,目前国内外尚缺乏有效的治疗方案。近年来研究显示肠道菌群在认知功能障碍中可能起到了重要作用。本文旨在从肠道菌群的角度,对抑郁症患者发生认知功能障碍的相关研究进行综述,为肠道菌群在预防或治疗老年抑郁症患者认知功能障碍中提供理论依据。

Depression is currently one of the most common mental diseases. In the group of patients with de-pression, about two-thirds of patients with depression have varying degrees of cognitive impair-ment. Research shows that the cognitive deficit of depression may be a precursor symptom of Alz-heimer’s disease, but its mechanism is not clear, and there is a lack of effective treatment at home and abroad. Recent studies have shown that gut flora may play an important role in cognitive dys-function. The purpose of this paper is to review the relevant studies on cognitive dysfunction in pa-tients with depression from the perspective of intestinal flora, and to provide theoretical basis for the prevention or treatment of cognitive dysfunction in elderly patients with depression.