自噬在转铁蛋白受体调节妇科肿瘤中的研究进展

Research Progress of Autophagy in Transferrin Receptor Regulation of Gynecologic Tumors

自噬是一种进化上保守的自我降解过程,在维持细胞代谢和稳态上发挥至关重要的作用。在不同条件下,自噬在肿瘤进展中发挥着抑制或促进作用。铁是细胞生长的必需营养物质,通过转铁蛋白受体(TFRC)摄取铁是细胞吸收铁的最重要方式。自噬可以调节细胞铁稳态,自噬及铁代谢失衡均可以导致疾病和肿瘤的发生。在这篇综述中,我们讨论了自噬联合转铁蛋白在妇科肿瘤中的研究进展。

Autophagy is an evolutionarily conserved self-degradation that plays a crucial role in maintaining cellular metabolism and homeostasis. Autophagy plays an inhibitory or promotional role in tumor progression under different conditions. Iron uptake by transferrin receptor is the most important way for cells to absorb iron. Autophagy regulates intracellular iron homeostasis, and the deregula-tion of autophagy and iron metabolism can lead to disease and tumors. In this review, we discuss the progress of autophagy combined with transferrin receptor in gynecologic tumors.