亚临床库欣研究进展

Progress in Subclinical Cushing’s Syndrome

亚临床库欣综合征是指皮质醇自主分泌轻度增高而无典型库欣综合征临床表现、可以导致多种代谢异常的一种疾病,在临床上较库欣综合征常见;亚临床库欣综合征多见于肾上腺意外瘤的患者。随着当前医学研究、影像学技术的不断进展,亚临床库欣综合征的检出率在不断增加。亚临床库欣综合征可以造成葡萄糖代谢障碍、血脂异常、高血压、骨脆性增高、亚临床动脉粥样硬化、内脏脂肪堆积、感染风险高、肌肉损伤、情绪障碍和高凝状态等,但因无典型临床症状且起病隐匿、病程进展缓慢,在临床工作中容易被忽视。本文就近年来亚临床库欣综合征的研究进展做一综述。

Subclinical Cushing’s Syndrome refers to a mild increase in autonomous secretion of cortisol with-out the clinical manifestations of typical Cushing’s syndrome, and can lead to a variety of metabolic abnormalities, which is more common than Cushing’s syndrome;subclinical Cushing’s syndrome is most commonly seen in patients with adrenal adenomas. The detection rate of Subclinical Cushing’s Syndrome is increasing with the current advances in medical research and imaging technology. Subclinical Cushing’s Syndrome can cause impaired glucose metabolism, dyslipidemia, hyperten-sion, increased bone fragility, subclinical atherosclerosis, accumulation of visceral fat, high risk of infection, muscle damage, mood disorders and hypercoagulability, etc. However, it is easy to be ne-glected in clinical work because of the absence of typical clinical symptoms, insidious onset, and slow progression of the disease. In this article, we review the research progress of Subclinical Cush-ing’s Syndrome in recent years.