炎症性肠病患者叶酸补充治疗的研究进展

Research Progress in Folic Acid Supplementation Treatment in Patients with Inflammatory Bowel Disease

炎症性肠病是一种病因未明的慢性肠道炎性疾病,主要包括溃疡性结肠炎和克罗恩病。炎症性肠病患者营养不良的发生率较高,相关营养治疗研究不胜枚举。叶酸作为人体必需微量营养素之一,在炎症性肠病的治疗中愈发受到重视。国外最新营养指南建议给予叶酸缺乏的患者定期的叶酸水平监测,并提供相应强化补充治疗,但目前有关炎症性肠病患者叶酸综合补充治疗仍有争议。本文章就此病患者中叶酸缺乏情况及补充治疗等方面进行探讨和总结,为临床诊疗提供参考价值。

Inflammatory bowel disease is a chronic intestinal inflammatory disease with an unknown cause, mainly including ulcerative colitis and Crohn’s disease. The incidence of malnutrition in patients with inflammatory bowel disease is relatively high, and the relevant nutritional treatment studies are numerous. Folic acid, as one of the essential micronutrients, is receiving more and more atten-tion in the treatment of inflammatory bowel disease. The latest foreign nutrition guidelines rec-ommend regular folic acid level monitoring for patients with folic acid deficiency and provide cor-responding intensive supplementary treatment, but there is still controversy about the compre-hensive folic acid supplementation treatment for patients with inflammatory bowel disease. This article discusses and summarizes folic acid deficiency and supplementary treatment in patients with this disease to provide reference value for clinical diagnosis and treatment.