转铁蛋白受体CD71在脓毒症诊疗及预后中的研究进展

Research Progress of Transferrin Receptor CD71 in Diagnosis Treatment and Prognosis of Sepsis

脓毒症是重症监护病房患者的主要死亡原因,由于缺少特异性诊断标志物和针对性治疗,其死亡率一直居高不下。转铁蛋白受体1 (Transferrin Receptor 1, TfRl),即CD71分子,是一种参与铁代谢和调节细胞生长所必需的膜蛋白,其在许多类型的细胞表面均有表达,与细胞的成熟、增殖、分化密切相关。近年来研究发现铁代谢在脓毒症中意义重大,同时铁死亡被证实在脓毒症的病程发展中发挥着重要的作用,这使铁代谢的研究具有重大的意义。本文综述了脓毒症中铁代谢的研究现况以及转铁蛋白受体1在临床中的相关应用,通过分析其共同的病理生理过程,以期找到更多转铁蛋白受体CD71在脓毒症中表达的意义,为帮助鉴别诊断脓毒症,判断患者病情严重程度,指导预后等提供潜在的生物标志物,同时为脓毒症提供新的干预靶点和治疗手段。

Sepsis is the main cause of death of patients in intensive care unit. Due to the lack of specific diag-nostic markers and limited treatment, the incidence and mortality of patients with sepsis have been high. Transferrin receptor 1 receptor 1 (CD71) is a necessary membrane protein involved in iron metabolism and regulating cell growth. It is expressed on many types of cells and is closely re-lated to cell maturation, proliferation and differentiation. In recent years, studies have found that iron metabolism is of great significance in sepsis, and iron death has been proved to play an im-portant role in the development of sepsis, which makes the study of iron metabolism of great signif-icance. This article reviews the research status of iron metabolism in sepsis and the related clinical application of transferrin receptor receptor 1, through the analysis of its common pathophysiologi-cal process, in order to find thesignificance of TfRl (CD71) expression in sepsis, and to provide po-tential biomarkers for differential diagnosis of sepsis, judging the severity of patients and guiding prognosis. At the same time, it provides new intervention targets and treatment methods for sepsis.