影响醛固酮水平升高的相关因素研究进展

Research Progress on Related Factors Affecting Elevated Aldosterone Levels

醛固酮是肾素–血管紧张素–醛固酮系统(RAAS)的一员,是参与调节水、电解质和血压稳态的主要盐皮质激素。醛固酮合成和分泌的调节主要受到促肾上腺皮质激素、循环钾浓度和血管紧张素II等刺激物的影响。近年来,大量研究已表明醛固酮作为体内的重要激素之一,醛固酮的过度分泌或调节失调在高血压、糖尿病、肥胖、肾病及心血管疾病的发生和发展中起重要作用。因此,早期认识醛固酮水平升高的相关因素及控制醛固酮水平可能是醛固酮介导的一系列疾病的预防和控制的一个环节。然而,醛固酮水平升高的影响或调节因素中,有些因素尚不够清楚或存在争议。在这篇综述中我们将总结影响醛固酮水平升高的相关因素。

Aldosterone is a member of the renin-angiotensin-aldosterone system (RAAS) and is the major mineralocorticoid involved in the regulation of water, electrolytes and blood pressure homeostasis. The regulation of aldosterone synthesis and secretion is mainly influenced by stimulants such as corticotropin, circulating potassium concentrations, and angiotensin II. In recent years, a lot of studies have shown that aldosterone is one of the important hormones in the body, and the exces-sive secretion or dysregulation of aldosterone plays an important role in the occurrence and devel-opment of hypertension, diabetes, obesity, kidney disease and cardiovascular diseases. Therefore, an early understanding of the factors associated with elevated aldosterone levels and the control of aldosterone levels may be a link in the prevention and control of a range of aldosterone-mediated diseases. However, some of the effects or regulators of aldosterone levels are not clear enough or controversial. In this review, we will summarize the influencing factors and regulators of elevated aldosterone levels.