摘要
肠道菌群通过多种途径参与2型糖尿病(T2DM)的发生发展过程,导致胰岛素抵抗(IR)、胰岛β细胞功能损伤和糖原合成及代谢紊乱,不断推动糖脂代谢并发症的发展。胆汁酸(BAs)作为肠道菌群代谢产物,与其内源性受体结合,包括法尼醇X核受体(FXR)和G蛋白偶联胆汁酸受体1 (TGR5),对T2DM产生影响。本文对肠道菌群–胆汁酸轴与T2DM关系的内在机制及相互影响进行综述。
Intestinal flora participates in the occurrence and development of type 2 diabetes (T2DM) through various ways, leading to insulin resistance (IR) and pancreatic islets β damage to cellular function and disruption of glycogen synthesis and metabolism, continuing to drive the development of com-plications in glycolipid metabolism. Bile acids (BAs), as metabolites of Intestinal flora, bind to their endogenous receptors, including farnesol X Nuclear receptor (FXR) and G protein coupled Bile acid receptor 1 (TGR5), which affect T2DM. This article reviews the internal mechanism and interaction between Intestinal flora-Bile acid axis and T2DM.
出处
《临床医学进展》
2023年第12期19851-19856,共6页
Advances in Clinical Medicine
