系统性红斑狼疮患者宫颈HPV感染特点及疫苗安全性研究进展

Research Progress on Cervical HPV Infection Characteristics and Vaccine Safety in Patients with Systemic Lupus Erythematosus

高危型HPV持续感染与宫颈癌和宫颈癌前病变密切相关,HPV的清除与机体的免疫功能有关。SLE患者由于自身免疫系统紊乱,发生HPV感染及宫颈病变的风险增加。HPV疫苗极大降低HPV感染的风险,对于SLE患者应积极接种HPV疫苗。本文综述系统性红斑狼疮患者宫颈HPV感染特点及疫苗安全性相关研究进展,为SLE患者宫颈癌筛查及HPV疫苗相关接种及研发提供参考。

The persistent infection of high-risk HPV is closely related to cervical cancer and cervical precan-cerous lesions, and the clearance of HPV is related to the immune function of the body. Patients with SLE are at increased risk of HPV infection and cervical lesions due to autoimmune disorders. HPV vaccine greatly reduces the risk of HPV infection and should be actively vaccinated in SLE patients. This article reviewed the characteristics of cervical HPV infection in patients with systemic lupus erythematosus and the relevant research progress of vaccine safety, so as to provide references for cervical cancer screening and HPV vaccine related vaccination and research and development in SLE patients.