植物提取物治疗牙龈组织创伤愈合的研究进展

Advances in the Treatment of Gingival Tissue Wound Healing with Plant Extracts

牙龈创伤愈合对牙周病和外科手术具有重要意义。牙龈创伤愈合是一个复杂的过程,涉及细胞与细胞外基质的各种成分以及细胞的迁移和增殖。与皮肤创伤相似,牙龈创伤愈合主要经历了止血、炎症、增殖和重塑四个阶段。口腔内的创伤是常见的,然而使用传统的外用药难以保护创口,容易使创伤部位受到微生物感染而进一步加剧。近些年来,科学家们一直在开发使用天然植物提取物作为外用药物治疗牙龈创伤,是目前治疗牙龈组织创伤愈合的研究热点。本文就目前用于治疗牙龈创伤常用的植物提取物类药物作一综述。

Gingival wound healing is of great importance in periodontal disease and surgery. Gingival wound healing is a complex process involving cells with various components of the extracellular matrix as well as cell migration and proliferation. Similar to skin wounds, gingival wound healing undergoes four main stages: hemostasis, inflammation, proliferation, and remodeling. Because wounds in the oral cavity are common, however, it is difficult to protect the wounds using traditional topical med-ications, which can easily further aggravate the wound site by microbial infection. In recent years, scientists have been developing the use of natural plant extracts as topical agents for the treatment of gingival wounds, which is currently a hot research topic in the treatment of gingival tissue wound healing. In this paper, we present a review of the plant extracts commonly used for the treatment of gingival wounds.