同型半胱氨酸与高血压靶器官损害相关研究进展

Research Progress on the Correlation between Homocysteine and Hypertensive Target Organ Damage

高血压作为全球性卫生问题,其导致的靶器官损害与患者预后密不可分,除了严格的降压管理,其他相关因素对高血压相关靶器官损害的影响越来越受到人们的重视。同型半胱氨酸(homocysteine, Hcy)自1932年被发现以来,其在高血压、心脑血管疾病中的致病作用被越来越多的研究证实。HHcy在高血压患病人群中患病率居高不下,这些人群中靶器官损害,及心脑血管并发症发生率较普通高血压患者高。本文将对Hcy、Hcy血症(hyperhomocysteinemia, HHcy)、H型高血压、高血压靶器官损害以及伴有HHcy的高血压患者的靶器官损害的相关研究进展进行综述。

Hypertension is a global health problem, and the target organ damage caused by it is closely related to the prognosis of patients. In addition to strict antihypertensive management, the influence of other related factors on the target organ damage related to hypertension has been paid more and more attention. Since homocysteine (Hcy) was discovered in 1932, its pathogenic role in hyperten-sion and cardiovascular and cerebrovascular diseases has been confirmed by more and more stud-ies. The prevalence of HHcy is high in hypertensive patients, and the incidence of target organ damage and cardiovascular and cerebrovascular complications in these patients is higher than that in ordinary hypertensive patients. This article will review the research progress of Hcy, hyperho-mocysteinemia (HHcy), H-type hypertension, hypertensive target organ damage and target organ damage in hypertensive patients with HHcy.