脂蛋白在2型糖尿病与冠心病患者动脉粥样硬化中的作用机制

The Mechanism of Lipoprotein in Atherosclerosis in Patients with Type 2 Diabetes and Coronary Heart Disease

2型糖尿病的发病率在世界范围内呈上升趋势。据估计,到2045年,全球糖尿病患者将达到7.832亿。虽然近年来2型糖尿病控制率得到很大程度的提高,但心血管疾病仍然是其死亡的一个重要原因,特别是冠状动脉粥样硬化性心脏病(简称冠心病)。冠心病是以动脉粥样硬化为病变基础,而糖尿病对动脉粥样硬化病变的发生和进展具有叠加作用,超过血脂异常本身,表明糖尿病诱导的脂代谢紊乱可能加速糖尿病相关的动脉粥样硬化。因此,本文就脂蛋白在2型糖尿病与冠心病患者动脉粥样硬化中的作用机制综述如下。

The incidence rate of type 2 diabetes is on the rise worldwide. It is estimated that by 2045, the number of diabetes patients worldwide will reach 783.2 million. Although the control rate of type 2 diabetes has been greatly improved in recent years, cardiovascular disease is still an important cause of death, especially coronary atherosclerotic heart disease (CHD). Coronary heart disease is based on atherosclerosis, and diabetes has a superimposed effect on the occurrence and progress of atherosclerosis, exceeding the dyslipidemia itself , indicating that diabetes induced lipid metabo-lism disorder may accelerate diabetes related atherosclerosis. Therefore, this article reviews the mechanism of lipoproteins in atherosclerosis in patients with type 2 diabetes and coronary heart disease.