肠道微生物群对帕金森病的研究进展

Research Progress of Gut Microbiota on Parkinson’s Disease

帕金森(PD)在我国老年人的发病率居高不下,对于其发病机制目前尚不完全清楚。肠道微生物是健康和疾病研究的新前沿,不仅许多疾病与微生物区系紊乱有关,而且越来越多的研究指出了因果关系。近年来的研究发现帕金森与肠道微生物群密切相关。本文通过对相关研究文献的整理,总结了PD与肠道菌群之间的相关机制,并在治疗方面总结了饮食干预、粪便移植、益生菌等改善帕金森患者的症状。以期能通过肠道微生物群为PD提供新的治疗策略。

The incidence of Parkinson’s disease (PD) in the elderly is very high in our country, and the patho-genesis of PD is not completely clear at present. Gut microbes are a new frontier in health and dis-ease research, and not only many diseases are associated with microbiota disturbances, but more and more studies are pointing to cause-and-effect relationships. Recent studies have found that Parkinson’s disease is closely related to the gut microbiome. Based on the review of relevant re-search literature, this paper summarized the mechanism between PD and gut microbiota, and summarized the improvement of symptoms of Parkinson’s patients with dietary intervention, fecal transplantation and probiotics in terms of treatment, in order to provide a new treatment strategy for PD through gut microbiota.