基于Web of Science的阿尔茨海默症伴抑郁症状的文献计量学分析

Bibliometric Analysis of Alzheimer’s Disease with Depressive Symptoms Based on Web of Science

目的:分析近5年阿尔茨海默症(Alzheimer’s disease)伴抑郁症状的研究现状和发展趋势,为国内外相关研究提供参考。方法:计算机检索Web of Science核心数据库,纳入2018~2022年发表的有关AD伴抑郁症状的英文文献,使用CiteSpace 6.1R6软件分别进行国家、机构、作者分析和关键词分析。结果:共纳入2655篇文献,美国的发文量最多,其次是中国;主要研究机构为高等院校;代表作者是HERRMANN,高频关键词有Alzheimer’s disease、dementia、depression、mild cognitive im-pairment等。该领域包含18个关键词聚类结果,演化路径可归纳为病理机制和影像学表现时期、危险因素和不良健康结局时期、干预治疗时期。结论:AD伴抑郁症状的研究热度逐年上升,机构、研究者之间可进一步加强合作,研究热点涉及AD伴抑郁症状的病理机制、危险因素、不良健康结局,AD伴抑郁症状的干预与治疗是未来的发展趋势。

Objective: To analyze the current research status and development trend of Alzheimer’s disease (AD) with depressive symptoms in the past 5 years, and to provide reference for domestic and in-ternational related research. Methods: A computerized search of the Web of Science core database was performed to include English-language literature on AD with depressive symptoms published from 2018 to 2022, and the data were processed using CiteSpace 6.1R6 software, with country, in-stitution, author analysis and keyword analysis performed separately. Results: A total of 2655 documents were included, The United States has the highest number of publications, followed by China;the main research institutions are institutions of higher learning;the representative author was HERRMANN, and the high-frequency keywords were Alzheimer’s disease, dementia, depres-sion, mild cognitive impairment, etc. The field contains 18 keyword clustering results, and the evo-lutionary path can be categorized into the period of pathological mechanisms and imaging mani-festations, the period of risk factors and adverse health outcomes, and the period of intervention and treatment. Conclusion: The research fever of AD with depressive symptoms is increasing year by year, and the cooperation between institutions and researchers can be further strengthened, and the research hotspots involve the pathological mechanisms, related risk factors, and adverse health outcomes of AD with depressive symptoms;the intervention and treatment of AD with de-pressive symptoms are the future development trend.