硅油在视网膜脱离应用中对视网膜的影响

Effect of Silicone Oil on the Retina in Retinal Detachment Applications

硅油(SO)在视网膜脱离手术中的应用已有60余年的历史,经过了硅油本身材料的改进和手术技术的发展,硅油已经成为眼科常用的材料之一,但其仍有临床上难以解释的并发症。我们在PubMed上搜索了自1962年硅油的第一篇报道后的与硅油视网膜相关的文献,特别是对相对权威的综述文献和基础实验文献,总结了硅油的特性、特别是乳化作用和小分子化合物的负面作用。分析了视网膜的结构,硅油对于视网膜组织的病理免疫影响以及最后临床并发症。最后对正在研发的玻璃体替代物进行简单的叙述,使眼科医生重视硅油所带来的负面效应,确保在使用硅油时考虑其性质及临床收益,并对硅油术后并发症的底层改变有新的认识。

Silicone oil (SO) has been used in retinal detachment surgery for more than 60 years. Through the improvement of silicone oil material and the development of surgical technology, silicone oil has become one of the commonly used materials in ophthalmology, but there are still complications that are difficult to explain in clinical practice. We searched PubMed for the literature related to sil-icone oil retina since the first report of silicone oil in 1962, especially the relative authoritative re-view literature and basic experimental literature, summarizing the characteristics of silicone oil, especially the emulsification effect and the negative effects of small molecular compounds. The structure of the retina, the pathological and immunological effects of silicone oil on retinal tissue and the final clinical complications were analyzed. Finally, the developing of vitreous substitutes for simple narrative, make an eye doctor attaches great importance to the negative effects brought by the silicone oil, to ensure that consider its properties and clinical benefits when using silicone oil, and the underlying change of silicone oil postoperative complications have a new understanding.