脓毒症相关生物标志物的研究进展

Research Progress on Sepsis-Related Biomarkers

脓毒症是发病率和死亡率都极高的疾病。脓毒症的临床表现无特异性且发病机制也极其复杂,这导致了脓毒症的早期诊断变得困难。临床上及早的诊断脓毒症,及时地给予抗生素治疗,可以挽救患者的生命。所以寻找简便、特异性和敏感性都高的生物标志物,对于脓毒症的早期诊断、预后判断都极为重要。本文对目前临床上已使用的生物标志物,和一些新发现的有潜力的生物标志物予以综述。

Sepsis is a disease with extremely high morbidity and mortality. The clinical manifestations of sep-sis are nonspecific, and the pathogenesis is extremely complex, which makes early diagnosis of sep-sis difficult. Early clinical diagnosis of sepsis and timely antibiotic treatment can save the patient’s life. Therefore, finding simple, specific, and sensitive biomarkers is extremely important for early diagnosis and prognosis of sepsis. This article reviews the biomarkers currently used clinically and some newly discovered potential biomarkers.