肿瘤微环境在弥漫大B细胞淋巴瘤中的研究现状

Research Status of Tumor Microenvironment in Diffuse Large B-Cell Lymphoma

弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma, DLBCL)是最常见的包含大细胞或转化B细胞的侵袭性异质性肿瘤,约占全部非霍奇金淋巴瘤的25%~50%。是一组高度分子异质性的疾病,细胞遗传学、基因表达谱和全基因组测序能够检测到多种复杂的染色体易位和遗传学异常。肿瘤微环境(tumor microenvironment, TME)是指肿瘤或癌干细胞存在的细胞周围环境,包括肿瘤周围的免疫细胞、血管、细胞外基质、成纤维细胞、肥大细胞和各类信号分子等。近年来,人们逐渐认识到肿瘤的增殖、浸润和转移既取决于肿瘤细胞自身,又依赖于TME中各种细胞以及信号分子的调控。随着人们对免疫治疗的研究进一步深入,TME作为肿瘤整体的重要组成部分,现在已经被认为对肿瘤的发生、发展以及治疗有着重要的调节作用。本文对TME在弥漫大B细胞淋巴瘤中的预后及治疗研究现状进行综述。

Diffuse large B-cell lymphoma (DLBCL) is the most common invasive and heterogeneous tumor containing large or transformed B cells, accounting for 25%~50% of all non-Hodgkin lymphomas. As a group of diseases with high molecular heterogeneity, cytogenetics, gene expression profiles, and whole genome sequencing enable the detection of multiple complex chromosomal transloca-tions and genetic abnormalities. Tumor microenvironment (TME) refers to the tumor or cancer stem cells of the surrounding environment, including immune cells, blood vessels around the tu-mor, extracellular matrix, fibroblasts, mast cells, and all kinds of signaling molecules, etc. In recent years, people have gradually realized that the proliferation, invasion and metastasis of tumors de-pend not only on the tumor cells themselves, but also on the regulation of various cells and signal-ing molecules in TME. With the further development of immunotherapy research, TME, as an im-portant part of the tumor as a whole, has been considered to have an important regulatory role in the occurrence, development and treatment of tumors. This article reviews the prognosis and treatment of TME in diffuse large B-cell lymphoma.