不同来源的外泌体对软骨细胞修复的作用

The Role of Exosomes from Different Sources on Chondrocyte Repair

颞下颌关节骨关节炎(temporomandibular joint osteoarthritis, TMJOA)是最常见的慢性退行性骨关节疾病,其病理特点是滑膜慢性炎症、软骨退变及软骨下骨吸收或硬化等。由于软骨的自愈能力有限,但目前对于完全缓解的治疗尚无共识。近年来,外泌体作为细胞间的通讯载体,能在细胞间传递生物活性脂质、核酸以及蛋白质等生物活性分子对软骨细胞产生一定影响,进而影响TMJOA的进展。本文就探讨不同来源的外泌体治对软骨细胞的作用机制与可行性做出综述。讨论不同来源的外泌体对软骨细胞的修复的作用,为骨关节炎的治疗提供新思路。

Temporomandibular joint osteoarthritis is the most common chronic degenerative osteoarthritic disease, and its pathology is characterized by chronic inflammation of the synovium, degeneration of the cartilage, and resorption or sclerosis of the subchondral bone. Due to the limited self-healing ability of cartilage, however, there is no consensus on the treatment for complete remission. In re-cent years, exosomes, as intercellular communication carriers, can deliver bioactive lipids, nucleic acids, and proteins and other biologically active molecules between cells to have a certain impact on chondrocytes, which in turn affects the progression of TMJOA. In this paper, we review the mecha-nism of action and feasibility of exploring the effects of exosomes from different sources on chon-drocytes. The role of exosomes from different sources on chondrocyte repair is discussed to provide new ideas for the treatment of osteoarthritis.