八段锦运动疗法联合二甲双胍对长期住院精神分裂症患者糖脂代谢的治疗作用

Therapeutic Effect of Baduanjin Exercise Therapy Combined with Metformin on Glycolipid Metabolism in Long-Term Hospitalized Schizophrenic Patients

目的:探讨八段锦运动疗法合并二甲双胍对女性精神分裂症患者的体重指数(BMI)和糖脂代谢的影响。方法:选取青岛市精神卫生中心收治的女性精神分裂症患者120例,按照随机数字表法分为观察组与对照组,每组60例。对照组口服二甲双胍。观察组在此基础上配合八段锦运动疗法。两组治疗时间均为12周。比较两组治疗前与治疗12周后体重和BMI、糖脂代谢相关指标的变化。结果:治疗组治疗前后体重、BMI、空腹血浆葡萄糖、糖化血红蛋白、低密度脂蛋白胆固醇和甘油三酯低于对照组(P > 0.05)。观察组治疗前后高密度脂蛋白胆固醇高于对照组(P > 0.05)。结论:八段锦运动疗法对于精神分裂症患者糖脂代谢具有改善作用,可以减少应用抗精神病药物患者的糖脂代谢紊乱。

Objective: To investigate the effects of Baduanjin exercise therapy combined with metformin on body mass index (BMI) and glycolipid metabolism in female patients with schizophrenia. Methods: 120 female patients with schizophrenia were selected from Qingdao Mental Health Center and di-vided into observation group and control group according to random number table, with 60 cases in each group. The control group received metformin orally. Observation group was combined with Baduanjin exercise therapy on this basis. Both groups were treated for 12 weeks. The changes of body weight, BMI and related indexes of glucose and lipid metabolism were compared between the two groups before treatment and 12 weeks after treatment. Results: The body weight, BMI, fasting plasma glucose, glycosylated hemoglobin, low density lipoprotein cholesterol and triglyceride in the treatment group were lower than those in the control group before and after treatment (P > 0.05). The high density lipoprotein cholesterol in observation group was higher than that in control group before and after treatment (P > 0.05). Conclusion: Baduanjin exercise therapy can improve the glu-cose and lipid metabolism in patients with schizophrenia, and can reduce the glucose and lipid me-tabolism disorder in patients with antipsychotic drugs.