GSDMD在肿瘤中的研究进展

Research Progress of GSDMD in Tumors

GSDMD属于gasdermin家族,是细胞焦亡通路当中的关键因子,其与gasdermin家族其他的因子包括GSDMA、GSDMB、GSDMC、GSDME和DFNB59一样都具有相同的双域结构,这种结构诱导了细胞焦亡的发生。细胞焦亡与机体的防御、炎症、自身免疫性疾病和许多其他系统性疾病中均存在着千丝万缕的联系,而GSDMD又作为细胞焦亡的关键触发点与许多疾病的发生都存在联系。本文就GSDMD在肿瘤当中的研究进展作一综述。

GSDMD is a member of the gasdermin family and plays a crucial role in the pyroptosis pathway. It has the same dual-domain structure as other members of the gasdermin family, such as GSDMA, GSDMB, GSDMC, GSDME, and DFNB59, which triggers pyroptosis. Pyroptosis is closely associated with the body’s defense, inflammation, autoimmune diseases, and many other systemic diseases. GSDMD, a critical trigger of pyroptosis, is associated with the development of numerous diseases. This article reviews the research progress on gasdermin D (GSDMD) in tumors.