Notch信号通路相关的非编码RNA在骨肉瘤中的研究进展

Research Progress of Non Coding RNA Related to Notch Signaling Pathway in Osteosarcoma

骨肉瘤是临床最常见的恶性成骨性肿瘤之一,具有发病率高、治愈率低的特点。Notch信号通路在调控骨肉瘤细胞增殖、凋亡、侵袭、迁移、血管生成,维持稳态等方面起重要作用,可能是预防骨肉瘤侵袭和转移的新型治疗策略。有研究证实非编码RNA如miRNA、lncRNA、circRNA等通过靶向Notch信号通路调控骨肉瘤的发生和发展,为治疗骨肉瘤提供一定的理论基础。本文章综述了Notch信号通路的组成,并重点阐述了相关非编码RNA靶向Notch信号通路在OS中的作用,对骨肉瘤的临床治疗和预后具有重要的临床意义。

Osteosarcoma is one of the most common malignant osteogenic tumors in clinic. It has the charac-teristics of high incidence rate and low cure rate. Notch signaling pathway plays an important role in regulating osteosarcoma cell proliferation, apoptosis, invasion, migration, angiogenesis and maintaining homeostasis. It may be a new therapeutic strategy to prevent osteosarcoma invasion and metastasis. Some studies have confirmed that noncoding RNAs such as miRNA, lncRNA and circRNA regulate the occurrence and development of osteosarcoma by targeting Notch signal path-way, which provides a theoretical basis for the treatment of osteosarcoma. This article reviews the composition of Notch signaling pathway, and focuses on the role of related non coding RNA targeted Notch signaling pathway in OS, which has important clinical significance for the clinical treatment and prognosis of osteosarcoma.