TyG指数与2型糖尿病性视网膜病变的关系研究

The Relationship between Triglyceride-Glucose Index and Type 2 Diabetic Retinopathy

目的:评估甘油三酯–葡萄糖指数(triglyceride glucose, TyG)与2型糖尿病性视网膜病变(DR)的关系。方法:横断面研究。收集2022年5月至2023年5月期间在我院内分泌科住院的235例2型糖尿病患者的临床资料,由空腹血糖及空腹甘油三酯计算TyG指数,将收集的2型糖尿病患者根据眼底检查结果分为DR组(160例)和无DR组(75例)。回归分析采取单因素和多因素Logistic回归分析,利用ROC曲线确立TyG指数的曲线下面积(AUC)及截断点,以及截断值的灵敏度和特异度,以上均以P < 0.05为差异有统计学意义。结果:DR组的TyG指数与无DR组的TyG指数差异有显著统计学意义。校正不同的混杂因素的结果均显示随着TyG指数的水平越高,DR患病率越高的趋势且有显著差异(P < 0.05)。TyG指数与2型糖尿病患者发生DR的风险显著相关,可以作为2型糖尿病患者发生DR的一个预测因子。结论:TyG指数与2型糖尿病性视网膜病变有关,对2型糖尿病患者发生DR具有预测价值。

Objective: To evaluate the relationship between the triglyceride-glucose index (triglyceride glucose, TyG) and type 2 diabetic retinopathy (DR). Method: A cross-sectional study. Clinical data of 235 pa-tients with type 2 diabetes mellitus hospitalized in the endocrinology department of our hospital from May 2022 to May 2023 were collected, and TyG index was calculated from fasting blood glu-cose and fasting triglycerides. The patients with type 2 diabetes mellitus were divided into DR (160) and no DR (75) according to the fundus examination results. The regression analysis used univariate and multivariate Logistic regression analysis, which established the area under the curve (AUC) and the TyG index, as well as the sensitivity and specificity of the cutoff value. P < 0.05 was significant. Results: There was a significant difference between the TyG index in the DR group and the TyG index in the no-DR group. Results adjusted for different confounders showed a trend towards higher prevalence of DR with the higher level of TyG index (P < 0.05). The TyG index was significantly associated with the risk of DR in patients with type 2 diabetes, and can be used as a predictor of DR in patients with type 2 diabetes. Conclusion: The TyG index is associated with type 2 diabetic retinopathy and has predictive value for developing DR in patients with type 2 DM.