泌尿系结石基质蛋白的研究现状

Research Status of Matrix Proteins in Urinary Calculi

泌尿系结石是全球范围内最常见的泌尿系统疾病之一,虽然是一种良性疾病,但由诸多因素作用。其发生及进展机制涉及众多生理及生化过程,然而,研究者们目前并没有彻底阐明这些机制。本综述旨在对泌尿系结石中基质蛋白(stones matrix protein, SMP)的研究进展做统一论述。希望能够通过汇总早先研究者们对各类泌尿系结石基质蛋白的研究,从而对泌尿系结石的产生与进展机制形成初步认识,以此为后续研究提供扎实的理论基础和研究方向。

Urinary calculi is one of the most common diseases of urinary system in the world. Although it is a benign disease, it is caused by many factors. The mechanisms of its occurrence and progression in-volve a number of physiological and biochemical processes, however, these mechanisms are not fully confirmed. The purpose of this review is to unify the research progress of stones matrix protein (SMP) in urinary calculi. By summarizing previous studies on SMP in various urinary calculi, we hope to have a preliminary understanding of the generation and progression mechanism of urinary calculi, so as to provide a solid theoretical basis and research direction for subsequent studies.