伴有快感缺乏的抑郁障碍患者奖赏网络功能变化研究进展

Research Progress on the Functional Changes of Reward Network in Patients with Depressive Disorder Accompanied by Anhedonia

抑郁障碍是最常见的精神疾病之一,快感缺乏是其核心症状,是指愉快体验能力的降低,在抑郁障碍患者中普遍存在,被证实是抗抑郁治疗预后差的预测因子,随着功能磁共振技术的发展,越来越多通过该方法的研究发现,具有快感缺乏的抑郁障碍患者与正常人相比,大脑奖赏网络各个脑区的功能变化存在差异,本文对具有快感缺乏的抑郁患者的奖赏网络内不同脑区功能变化的研究开展叙述。

Depressive disorder is one of the most common mental disorders, and anhedonia is its core symp-tom, which refers to the decrease of the ability to experience pleasure. It is common in depressive patients and has been confirmed as a predictor of poor prognosis in antidepressant treatment. With the development of functional magnetic resonance imaging technology, more and more studies us-ing this method have found that there are differences in the functional changes of various brain re-gions in the brain reward network between depressive patients with anhedonia and normal people. This paper describes the research on the functional changes of different brain regions in the reward network of depressive patients with anhedonia.