脓毒血症相关生物标志物的研究进展

The Research Progress of Septic Biomarkers

脓毒血症是由感染引起的危及生命的疾病。随着脓毒血症定义的不断演变,对其如何快速识别,用以及时治疗越发重要。由于脓毒血症机制复杂,临床症状及体征缺乏特异性,快速识别脓毒血症在临床工作中成为一项挑战,因此许多脓毒血症相关生物标志物的研究应运而生,但目前仍未能找到理想的生物标志物用来诊断脓毒血症、指导临床的治疗决策以及评估预后。该综述描述了生物标志物的研究现状,通过对现有脓毒血症生物标志物的深入理解,为其运用在脓毒血症的诊疗工作中提供参考。

Sepsis is a life-threatening condition caused by infection. As the definition of sepsis continues to evolve, it is becoming more and more important to identify it quickly for prompt treatment. Due to the complex mechanism of sepsis and the lack of specificity of clinical symptoms and signs, rapid identification of sepsis has become a challenge in clinical work. Therefore, many researches on septic biomarkers have emerged at the right time, but ideal biomarkers have not been found to diagnose sepsis, guide clinical treatment decisions and evaluate prognosis. This review describes the current research status of biomarkers for sepsis, and provides references for their application in the diagnosis and treatment of sepsis through in-depth understanding of the existing bi-omarkers.