幼年特发性关节炎预后相关生物标记物研究进展

Advances in the Study of Prognosis-Related Biomarkers in Juvenile Idiopathic Arthritis

幼年特发性关节炎(JIA)是最常见的儿童慢性风湿性疾病,以慢性关节滑膜炎为主要表现,可伴全身多脏器功能损害,严重威胁患儿的生存质量。相关生物标记物的发现可能有助于早期诊断、评估疾病活动水平、预测临床缓解与复发、预测对药物治疗的反应等,为实现幼年特发性关节炎的合理诊疗提供希望。

Juvenile idiopathic arthritis (JIA) is the most common chronic rheumatic disease in children, with chronic synovitis as the main manifestation, which can be associated with systemic multi-organ functional impairment, seriously threatening the quality of survival of children. The discovery of biomarkers may help in early diagnosis, assessment of disease activity level, prediction of clinical remission and recurrence, and prediction of response to drug therapy, offering hope for rational treatment of juvenile idiopathic arthritis.