脑小血管病与炎症的密切关系

The Close Relationship between Cerebral Small Blood Vessel Disease and Inflammation

脑小血管病近年来发病率逐年增加,造成了社会巨大的经济负担,与年龄相关的CSVD亦在逐年上升,最常见的表现是脑卒中及认知障碍。临床前研究和临床研究均提示脑小血管病与炎症存在一定的相关关系,因此本文综述了炎症和CSVD病理生理进展的最新研究。

In recent years, the incidence of cerebral small vascular disease has increased year by year, causing a huge economic burden on the society. The age-related CSVD is also increasing year by year. The most common manifestations are stroke, cognitive impairment, and even dementia. Both preclini-cal studies and clinical research suggest that there is a correlation between cerebral small vessel disease and inflammation. Based on this, this paper reviews the latest studies on the pathophysiol-ogy of inflammation and CSVD, and explores the potential link between inflammation and age-related CSVD, in order to provide new ideas for further research in diagnosis and treatment.