环形RNA在肿瘤中的研究进展

Research Progress of Circular RNA in Tumors

现阶段人们对非编码RNA不断研究,发现非编码RNA不仅参与人体的正常生理进展,还与疾病的发生有关,这些非编码RNA可能是疾病诊断和治疗的新途径。环形RNA (circular RNA, circRNA)是近些年来发现的与肿瘤有关的非编码RNA,在哺乳动物体内表达,能够调控基因的转录过程。circRNA是一个闭合环状结构,是一种内源性的RNA分子。近些年来的研究发现circRNA在很多不同来源的肿瘤疾病中发挥作用,例如:胃癌、乳腺癌、肝癌等,circRNA能够通过吸附相关的miRNA发挥作用,miRNA又影响下游靶基因的表达,因此circRNA可以同时参与多个生理和病理过程。我们对circRNA在肿瘤中的研究进展进行综述。

At present, people continue to study non-coding RNA, and find that non-coding RNA is not only in-volved in the normal physiological progress of human body, but also related to the occurrence of diseases. These non-coding RNAs may be a new way for disease diagnosis and treatment. Circular RNA (circRNA) is a non-coding RNA found in recent years, which is expressed in mammals and can regulate the transcription process of genes. CircRNA is a closed loop structure and an endogenous RNA molecule. In recent years, it has been found that circRNA plays a role in many tumor diseases from different sources, such as gastric cancer, breast cancer, liver cancer, etc. circRNA can play a role by adsorbing related miRNA, which in turn affects the expression of downstream target genes, so circRNA can participate in multiple physiological and pathological processes at the same time. We review the research progress of circRNA in tumors.