膜性肾病的研究进展

Advances in the Research of Membranous Nephropathy

膜性肾病(membranous nephropathy, MN)是具有共同的组织病理学模式的一种异质性疾病,常表现为肾病综合征(nephrotic syndrome, NS),是成人NS最常见的原因。MN的病因多样,其发病机制尚未完全阐明,但多认为与足细胞损伤有关,靶抗原的发现为其发病机制、诊断和治疗提供了新的方向。本文总结了MN的病因、分类、靶抗原,讨论其发病机制、病理特征等,以期为MN的早期诊断及治疗提供新的见解。

Membranous nephropathy (MN) manifests as a heterogeneous disease sharing a common histo-pathological pattern, frequently presenting as Nephrotic syndrome (NS), and stands as the pre-dominant cause of NS among adults. The etiology of MN exhibits considerable diversity, and its pathogenesis remains incompletely elucidated, albeit the prevailing belief in its association with podocyte injury. Notably, the identification of target antigens has introduced novel dimensions to the understanding of MN’s pathogenesis, diagnosis, and therapeutic strategies. This article endeav-ors to comprehensively delineate the etiological spectrum, classification intricacies, and pertinent target antigens characterizing MN. Furthermore, it delves into the nuanced exploration of its path-ogenesis and pathological attributes, thereby aiming to furnish novel perspectives conducive to the advancement of early diagnostic modalities and therapeutic interventions for MN.