肝内胆管癌系统治疗与局部治疗的现状及进展

Current Status and Progress of Systemic and Local Therapy for Intrahepatic Cholangiocarcinoma

肝内胆管癌是原发性肝癌的一种,发病率仅次于原发性肝细胞癌,其恶性程度高、预后差、早期临床症状不典型,多数患者确诊时已失去手术机会。对于中晚期肝内胆管癌的治疗通常以化疗为主,局部治疗手段有肝动脉化疗栓塞、放疗、射频消融治疗等。近年来,靶向及免疫治疗在各种实体肿瘤的应用愈加广泛,且取得了令人鼓舞的成绩。因此,随着各种治疗手段的不断进展,联合治疗似乎成为一种可行的治疗策略。本文就肝内胆管癌的系统治疗与局部治疗的现状及进展作如下综述。

Intrahepatic cholangiocarcinoma is a type of primary liver cancer, with an incidence rate second only to primary hepatocellular carcinoma. It has a high degree of malignancy, poor prognosis, and atypical early clinical symptoms. Most patients have lost the opportunity for surgery when diag-nosed. The treatment for intermediate and advanced intrahepatic cholangiocarcinoma is usually chemotherapy, and local treatment methods include hepatic arterial chemoembolization, radio-therapy, radiofrequency ablation, etc. In recent years, targeted and immunotherapy have been in-creasingly used in various solid tumors and have achieved encouraging results. Therefore, as var-ious treatments continue to advance, combination therapy appears to be a feasible treatment strat-egy. This article reviews the current status and progress of systemic treatment and local treatment of intrahepatic cholangiocarcinoma as follows.