肿瘤微环境与放疗敏感性的研究进展

Research Progress on Tumor Microenvironment and Radiotherapy Sensitivity

放射治疗是许多癌症的主要治疗方式,提供潜在的治疗结果。尽管放射治疗取得了成功,但肿瘤细胞可能对其产生抵抗,从而导致疾病复发。肿瘤微环境的组成部分可能在放疗的成功或失败中起着不可或缺的作用。为此,本综述讲述了微环境中成纤维细胞、免疫细胞、细胞外基质、肿瘤血管以及缺氧微环境对放疗敏感性的影响,以加深我们对肿瘤微环境与放疗敏感性关系的了解,有助于建立一个临床前的理论基础,以支持基质靶向药物与放疗联合使用以增加放射敏感性。

Radiotherapy (RT) is a primary treatment modality for a number of cancers, offering potentially curative outcomes. Despite its success, tumour cells can become resistant to RT, leading to disease recurrence. Components of the tumor microenvironment (TME) likely play an integral role in managing RT success or failure. This review describes the effects of cancer-associated fibroblast (CAF), immune cells, extracellular matrix (ECM), tumor blood vessels, and hypoxic microenvironment in the microenvironment on radio-therapy sensitivity, in order to deepen our understanding of the tumor microenvironment and ra-diotherapy sensitivity, and help establish a preclinical theoretical basis to support the combination of stromal-targeted drugs and radiotherapy to increase radiation sensitivity.