肥胖检测指标与PCOS合并IR的相关研究

Correlation Study of Obesity Detection Index and PCOS Combined with IR

多囊卵巢综合症(PCOS)是育龄期女性常见的生殖内分泌疾病,临床表现为月经异常、不孕、高雄激素血症或体征(多毛症,痤疮、脱发)、肥胖、胰岛素抵抗(IR)等。PCOS常伴有胰岛素抵抗,可引起糖脂代谢异常,从而使得2型糖尿病,高血压,心血管疾病的发生率升高。约50%~70%的PCOS患者存在IR,肥胖PCOS人群中IR可达75%,肥胖和PCOS共存更易发生IR和MS。持续存在IR及MS,其远期并发症如:2型糖尿病,高血压,心血管疾病的发生率也会升高。因此,对于IR的早期干预将有利于降低PCOS患者心血管疾病等远期并发症的发病风险。

Polycystic ovary syndrome (PCOS) is a common reproductive endocrine disease in women of childbearing age. The clinical manifestations include abnormal menstruation, infertility, hyper and rogenemia or signs (hirsutism, acne, alopecia), obesity, insulin resistance (IR), etc. PCOS is often ac-companied by insulin resistance, which can cause abnormal glucose and lipid metabolism, thus in-creasing the incidence of type 2 diabetes, hypertension, and cardiovascular diseases. About 50% to 70% of PCOS patients have IR, and the IR of obese PCOS patients can reach 75%. The coexistence of obesity and PCOS makes IR and MS more likely. Long-term complications such as type 2 diabetes, hypertension, and cardiovascular disease may also increase with the persistence of IR and MS. Therefore, early intervention for IR will help reduce the risk of cardiovascular disease and other long-term complications in PCOS patients.