脑性瘫痪的骨代谢生化指标研究进展

Research Progress on Biochemical Indicators of Bone Metabolism in Cerebral Palsy

脑性瘫痪(cerebral palsy, CP)被定义为是一组持续存在的中枢性运动和姿势发育障碍、活动受限症候群,这种症候群是由于发育中的胎儿或婴幼儿脑部非进行性损伤所致。CP的活动受限会引起继发性肌肉萎缩和骨骼损害,骨代谢的生化标记物可以实时地评估骨骼损害的进展,为评估CP的治疗效果及预后提供理论依据。本文对CP的骨代谢生化指标研究进展作一综述,阐述各骨代谢生化指标的意义及CP骨代谢生化指标的特点,为CP的骨骼研究提供参考。Cerebral palsy (CP) is defined as a persistent central motor and postural developmental disorder, limited mobility syndrome, caused by non progressive brain damage in developing fetuses or in-fants. The limited activity of CP can cause secondary muscle atrophy and bone damage. Biochemical markers of bone metabolism can evaluate the progression of bone damage in real time, providing a theoretical basis for evaluating the therapeutic effect and prognosis of CP. This article provides a review of the research progress on CP bone metabolism biochemical indicators, explaining the sig-nificance of each bone metabolism biochemical indicator and the characteristics of CP bone metabo-lism biochemical indicators, providing reference for CP bone research.