纳米磁性空心二氧化硅球的制备及其靶向作用的研究

Study on the Preparation of Nano Magnetic Hollow Silica Spheres and Their Targeting Effect

以官能化二氧化硅微球为模板,采用简单、绿色的方法制备了腔大小和壳厚均匀的磁性空心二氧化硅微球(MHSS)。通过改变[Fe2+]/[Fe3+]的摩尔比和铁盐的摩尔浓度,在SiO2表面沉积磁性颗粒(Fe3O4)。所制得的磁性空心硅球在室温下表现出超顺磁性。采用扫描电镜(SEM)、透射电镜(TEM)和x射线粉末散射(XRD)对MHSS进行了表征。结果表明,在0.10 M铁盐和2:1 [Fe2+]/[Fe3+]摩尔比条件下制备的MHSS样品具有较大的空腔空间和超顺磁性,内部氨基功能化的MHSS可以用放射性同位素99mTc标记,研究MHSS在体内的磁性靶向分布。这些结果表明MHSS在磁性靶向给药系统中的潜力。

The magnetic hollow silica spheres (MHSS) with uniform cavity size and shell thickness were pre-pared by a simple and “green” method using functionalized SiO2 spheres as templates. Magnetic particles (Fe3O4) were deposited on the SiO2 surface by varying the molar ratio of [Fe2+]/[Fe3+] and the molar concentration of iron salts. The obtained magnetic hollow silica spheres exhibited a su-per-paramagnetic behavior at room temperature. Scanning electron microscopy (SEM), transmis-sion electron microscopy (TEM), and X-ray powder scattering (XRD) were applied to characterize the MHSS. Besides, the MHSS sample prepared at 0.10 M iron salts and 2:1 molar ratio of [Fe2+]/[Fe3+] has a large hollow cavity space and super-paramagnetic characteristics, the inner amino-functio- nalized MHSS could be labeled with radioisotope 99mTc to study the MHSS’s magnetic targeting distribution in vivo. These results indicate the potential of MHSS in the magnetic targeted drug delivery system.