代谢组学在创伤性颅脑损伤中的研究进展

Research Progress of Metabonomics in Traumatic Brain Injury

创伤性脑损伤(Traumatic Brain Injury, TBI)作为世界上最常见的后天性脑损伤,是世界上最主要的死亡和致残原因之一。由于多种原因的受伤因素以及大脑的复杂性,创伤性颅脑损伤可以诱导多种病理生理学机制的改变。因此早期的诊断以及良好的预后治疗TBI的迫切问题。代谢物作为生物体内的主要组成部分,参与了各种循环途径。代谢组学技术通过检测出不同代谢物浓度变化反应生物某一时间点生理、生化状态的准确信息。可以用来诊断疾病的严重程度、损伤机制、监测治疗反应及评估预后等。当前的代谢组学分析平台已能够检测和量化小浓度代谢物,使得我们评估颅脑损伤更加客观化、精细化。本文综述了代谢组学作为独立平台在临床环境中对于TBI的诊断、评估预后的前景。

Traumatic brain injury (TBI), as the most common acquired brain injury in the world, is one of the most important causes of death and disability in the world. Due to various injury factors and the complexity of the brain, traumatic brain injury can induce changes in a variety of pathophysiologi-cal mechanisms. Therefore, early diagnosis and good prognosis are urgent problems in the treat-ment of TBI. As the main component of organism, metabolites participate in various circulation pathways. Metabonomics technology reflects the accurate information of biological physiological and biochemical state at a certain time point by detecting the changes of different metabolite con-centrations. It can be used to diagnose the severity, evolution, treatment and prognosis of the dis-ease. The current metabonomics analysis platform has been able to detect and quantify small con-centrations of metabolites, making our assessment of brain injury more objective and refined. This article reviews the prospect of metabonomics as an independent platform for evaluating TBI in clinical settings.