蛋白质组学的发展及其在急性髓系白血病中的应用

Development of Proteomics and Its Use in Acute Myeloid Leukemia

急性髓系白血病作为一种复发率高的造血系统恶性肿瘤,其分子机制、预后预测以及药物反应一直是这个疾病诊疗的关键,而近年来飞速发展的蛋白质组学技术也逐渐进入了急性髓系白血病应用研究领域。该文对急性髓系白血病蛋白质组涉及的技术进行了回顾,总结了急性髓系白血病蛋白质组研究及应用的进展。

As a hematopoietic malignancy with high recurrence rate, acute myeloid leukemia’s molecular mechanism, prognosis prediction and drug response have always been the key to the diagnosis and treatment of this disease. The rapid development of proteomics technology in recent years has gradually entered the applied research field of acute myeloid leukemia. This paper reviews the techniques involved in the acute myeloid leukemia proteome and summarizes the progress of the acute myeloid leukemia proteome study and application.