摘要
过氧化物酶体增殖激活受体(PPARs)是配体激活的转录因子,属于核激素受体家族。PPARs具有3种亚型:PPARα、PPARβ/δ和PPARγ,具有不同组织分布和细胞功能。3种PPARs亚型均在皮肤中有分布,参与皮肤细胞的脂质代谢与能量代谢,与角质形成细胞的增殖和分化密切相关,调节成纤维细胞的分泌功能,介导皮脂腺的生成与免疫稳态的维持,促进黑色素细胞的分化和黑素小体的成熟,并对促进毛囊的分化发育有益。基于PPARs在皮肤中的生物学效应,PPAR激动剂或拮抗剂可能为治疗各种皮肤疾病提供新的机会。
Peroxisome proliferator-activated receptors (PPARs) are ligand-activated transcription factors belonging to the nuclear hormone receptor family. The 3 isoforms of PPARs, which are PPARα, PPARβ/δ, and PPARγ, have different tissue distributions and cellular functions. PPARs are also found in the skin and are involved in the lipid metabolism and energy metabolism of skin cells and are closely related to proliferation and differentiation of keratinocytes and the regulation of the secretion of fibroblasts, mediate the production of sebaceous glands and the maintenance of immune homeostasis. They also promote the differentiation of melanocytes and the maturation of melanosomes. Besides, they are beneficial for the promotion of hair follicles. Based on the biological effects of PPARs in the skin, PPAR agonists or antagonists may provide new opportunities for the treatment of various skin diseases.
出处
《临床医学进展》
2024年第3期1396-1404,共9页
Advances in Clinical Medicine
