代谢功能障碍相关脂肪性肝病与心血管疾病:病理生理学机制

Metabolic Dysfunction-Associated Fatty Liver Disease and Cardiovascular Disease: Pathophysiological Mechanisms

代谢功能障碍相关脂肪性肝病(metabolic dysfunction-associated fatty liver disease, MAFLD)是最普遍的慢性肝病之一,但MAFLD患者死于心血管疾病(cardiovascular disease, CVD)的频率高于肝脏疾病本身。与MAFLD相关的病理生理研究表明存在与CVD相关的潜在机制,涉及全身炎症、氧化应激、胰岛素抵抗(insulin resistance, IR)、糖脂代谢、肾素–血管紧张素系统(rein-angiotensin system, RAAS)和交感神经系统(sympathetic nervous system, SNS)、肠道微生物群以及遗传,促进CVD事件的发生。这篇综述分析了MAFLD和CVD之间的关系,概述了可能将MAFLD与CVD联系起来的潜在病理生理机制。

Metabolic dysfunction-associated fatty liver disease (MAFLD) is a common chronic liver disease, but patients with MAFLD are more likely to die from cardiovascular disease (CVD) rather than liver disease itself. Pathophysiological studies have shown that there are potential mechanisms associated with CVD in MAFLD, including systemic inflammation, oxidative stress, insulin resistance, glucose and lipid metabolism, the Renin-angiotensin system(RAAS) and sympathetic nervous system(SNS), the gut microbiota, and genetics. These factors contribute to the development of CVD events. This review aims to analyze the relationship between MAFLD and CVD and discuss the potential pathophysiological mechanisms that connect the two conditions.