鼓膜修补的组织工程材料研究进展

Research Progress of Tissue Engineering Materials for Tympanic Membrane Repair

鼓膜穿孔(Tympanic Membrane Perforation, TMP)是耳鼻喉科常见的疾病之一,会导致听力下降、中耳炎、胆脂瘤等问题,大多数急性穿孔的鼓膜(Tympanic Membrane, TM)具有自发愈合能力,但慢性穿孔需要手术干预。然而,外科手术的缺点包括感染、麻醉风险等一系列并发症及禁忌症。组织工程的发展为鼓膜修补提供新的治疗策略,许多新型材料在鼓膜修补中取得良好效果,本文综述通过总结分析组织工程材料在鼓膜修补的最新研究进展,为临床治疗及研究提供思路。

Tympanic membrane perforation (TMP) is one of the common diseases in otolaryngology, which can cause hearing loss, otitis media, cholesteatoma and other problems. Most acutely perforated Tympanic Membrane (TM) has spontaneous healing ability, but chronic perforation requires surgical intervention. However, the disadvantages of surgery include infection, risk of anesthesia, and risk of graft absence or deformation failure. The development of tissue engineering provides new treatment strategies for tympanic membrane repair, and many new materials have achieved good results in tympanic membrane repair. This review summarizes and analyzes the latest research progress of tissue engineering materials in tympanic membrane repair, providing ideas for clinical treatment and research.