近红外荧光成像在泌尿系肿瘤中的研究进展

Research Progress on Specific Imaging of NIR-II Fluorescence Imaging in Urological Tumors

恶性肿瘤严重威胁着人类的生命健康,其中泌尿系三大肿瘤的发病率和死亡率也在不断上升,早期诊断、早期治疗可以显著改善肿瘤患者的预后。荧光成像(fluorescence imaging, FLI)可以进行实时、无创、高时空分辨率的成像,准确获取体内动态生物信息,对癌症的早期诊断和治疗具有重要作用。得益于近红外波段(Near-infrared, NIR)较强的穿透能力,有利于实现大的提高成像深度和高空间分辨率,突破了组织深部的成像限制。目前,荧光成像技术已用于肿瘤的特异性成像、手术辅助导航和光热治疗中,因此本文就NIR荧光成像在泌尿系肿瘤中特异性显像的研究进展作一综述。

Malignant tumors pose a serious threat to human life and health, among which the incidence rate and mortality of the three major tumors of the urinary system are also rising. Early diagnosis and early treatment can significantly improve the prognosis of tumor patients. Fluorescence imaging (FLI) can provide real-time, non-invasive, and high spatiotemporal resolution imaging, accurately obtaining dynamic biological information in the body, and plays an important role in the early diagnosis and treatment of cancer. Thanks to the strong penetration ability of the Near infrared (NIR) band, it is conducive to achieving significant improvements in imaging depth and high spatial resolution, breaking through the imaging limitations of deep tissues. At present, fluorescence imaging technology has been used in tumor specific imaging, surgical assisted navigation, and photothermal therapy. Therefore, this article reviews the research progress of NIR fluorescence imaging in specific imaging of urinary system tumors.